| New structures last month: | 56 |
| Total structures to date: | 5822 |
| Total distinct structures: | 4908 |
| Total community structures: | 525 |
Current Focus
Immune System
Featured System
Tuning Immune Response with Costimulation
PSI researchers are studying molecules that stimulate and inhibit our immune response, ensuring that it is activated only when necessary.
Read MoreResearch Advances
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The Immune System: Strand Swapping for T-Cell Inhibition
Read More
An immunoglobulin protein with a role in antigen-independent T-cell signaling dimerizes via a strand-swapped interface. -
The Immune System: A Strong Competitor
Read More
HLA-DO is an MHCII mimic that prevents the association of HLA-DM to MHCII.
Technical Highlights
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The Immune System: A Brotherhood of Immunoglobulins
Read More
The Brotherhood algorithm groups proteins into functional families using indirect sequence similarity. -
The Immune System: Super Cytokines
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Crystal structures of cytokine receptor complexes pinpoint target regions to create 'superkines' with altered cell specificity.
Latest PSI Results
Centers: NESG
PDBID: 4JXI
Directed evolution and rational design of a de novo designed esterase toward improved catalysis. Northeast Structural Genomics Consortium (NESG) Target OR184
Centers: NYSGRC
PDBID: 4K93
CRYSTAL STRUCTURE OF probable sugar kinase protein from Rhizobium etli CFN 42 complexed with N-(HYDROXYMETHYL)BENZAMIDE
Centers: NYSGRC
PDBID: 4K9C
CRYSTAL STRUCTURE OF probable sugar kinase protein from Rhizobium etli CFN 42 complexed with N-(HYDROXYMETHYL)BENZAMIDE and 4-METHYL-3,4-DIHYDRO-2H-1,4-BENZOXAZINE-7-CARBOXYLIC ACID
Centers: NYSGRC
PDBID: 4K9I
CRYSTAL STRUCTURE OF probable sugar kinase protein from Rhizobium etli CFN 42 complexed with Norharmane
Centers: NYSGRC
PDBID: 4KA0
Crystal structure of a putative thiol-disulfide oxidoreductase from Bacteroides vulgatus (target NYSGRC-011676), space group P21221
Centers: NYSGRC
PDBID: 4KAD
Crystal structure of probable sugar kinase protein from Rhizobium etli CFN 42 complexed with N1-(2.3-dihydro-1H-inden-5-yl)acetam
Centers: NYSGRC
PDBID: 4KAH
Crystal structure of probable sugar kinase protein from Rhizobium etli CFN 42 complexed with 4-bromo-1H-pyrazole
Centers: NYSGRC
PDBID: 4KAL
Crystal structure of probable sugar kinase protein from Rhizobium etli CFN 42 complexed with quinoline-3-carboxylic acid
Centers: NYSGRC
PDBID: 4KAN
Crystal structure of probable sugar kinase protein from Rhizobium etli CFN 42 complexed with 2-(2,5-dimethyl-1,3-thiazol-4-yl)acetic acid
Centers: NYSGRC
PDBID: 4KBE
Crystal structure of probable sugar kinase protein from Rhizobium etli CFN 42 complexed with benzoguanamine
Centers: MCSG
PDBID: 4KLV
Crystal structure of a GNAT superfamily acetyltransferase PA4794 in complex with 4-methylumbelliferyl phosphate
Centers: MCSG
PDBID: 4KLW
Crystal structure of a GNAT superfamily acetyltransferase PA4794 in complex with 2-(aminocarbonyl)benzoate
Centers: NYSGRC
PDBID: 4KNP
Crystal Structure Of a Putative enoyl-coA hydratase (PSI-NYSGRC-019597) from Mycobacterium avium paratuberculosis K-10
Centers: NYSGRC
PDBID: 4KPK
Crystal structure of a enoyl-CoA hydratase from Shewanella pealeana ATCC 700345
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